Dynamics of the Parameters of Platelet Hemostasis in Patients with Ischemic Stroke after Systemic Thrombolytic Therapy

Abstract

Were examined 89 patients with ischemic stroke (IS) (mean age 58.54 (55.05, 64.73)), 42 of them with systemic thrombolytic therapy (TLT) (mean age 64.26 )60.58; 68,06)) and 47 patients with IS without TLT (54,52 (47,48, 60,83)). In the subgroup of moderate severity (from 7 to 14 points in NIHSS) included 13 patients after TLT, of severe severity (more than 15 points for NIHSS) included 29 patients after TLT. The determination of platelet hemostasis was carried out by the method of Born and O'Brien with the determination of aggregation, sizes of platelet aggregates for adrenaline, аdenosine diphosphate (ADP), ristomycin, spontaneous aggregation and fibrinogen concentrations on days 1, 7 and 14. Clinical evaluation of the severity of the condition was carried out according to the NIHSS scale. Specific features of changes in platelet hemostasis in inducers (adrenaline, ristomycin, ADP) in patients with IS after TLT at 1, 7 and 14 days in comparison with the indices of patients without TLT and their relationship with the dynamics of neurologic deficit, which allow to clarify the features of the vascular flow process, its forecast.