Abstract
The potential diagnostic effectiveness and dynamics of the physicochemical and biochemical properties of urine in rabbits with a lifetime experimental model of retroperitoneal hematoma were studied. As a result of the studies, it has been established that there are no reliably significant deviations in the reaction (pH) and relative density of urine between the animals of the experimental and control groups, and it indicates that the retroperitoneal hematoma we simulated, does not have a significant effect on the kidneys ability to maintain acid levels-basic balance, as well as dilute and concentrate urine. The average urine reaction (pH) values in rabbits in both groups range from 7.4±0.2 to 8.0±0.2, and the relative density – from 1.027±0.001 to 1.031±0.003 g/ml. The protein content in the rabbits urine after the formation of a lifetime experimental model of retroperitoneal hematoma is significantly higher in comparison with the control group at all times, and gamma-glutamyl transpeptidase (GGT) is only up to the 14th day of the experiment, while the creatinine content does not reliably change in individuals of the control and experimental groups they are within the limits from 124.4±18.9 to 148.1±22.9 mg/dl. A reliably significant increase in the concentration of protein and GGT in the urine, in addition to the absence of significant changes in the creatinine content in the urine of the experimental group, in comparison with the control group, gives grounds to expect the presence of kidney damage, and, therefore, biochemical parameters of urine can act as an objective diagnostic marker of the involvement of these organs into the pathological process with retroperitoneal hematoma.
Published Version
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