Dynamics of indicators of C-reactive protein and procalcitonin in the oral fluid of patients with plastic oroantral communication

Abstract

Relevance. The most frequent complication in surgeries of tooth extraction on the upper jaw is perforation of the upper jaw sinus. Plastic surgery is necessary to eliminate the appeared communication. Prior to this, the dentist-surgeon should be sure of absence of chronic polyposes process in the sinus. At present the usual roentgenogram of the paranasal sinus is often proved to be not informative, while taking computer tomography is often not available in many cases either. The biochemical methods of studies of oral fluid is of possible concern in diagnostics of chronic inflammatory processes in the sinus. Purpose . To study the dynamics of indicators of C-reactive protein and procalcitonin in the mixed saliva of patients with plastic oroantral communication caused by tooth extraction. Materials and methods . There were studied the indicators of two inflammation markers (C-reactive protein and procalcitonin) in 62 patients of the age from 20 to 45 with oroantral communications. The patients were studied with the help of cone beam computer tomography either and after that they were divided into 2 groups. The first group included patients without x-ray signs of chronic sinus inflammation. The second group was formed by patients with marked signs of chronic inflammation of the maxillary sinus mucosa. There was studied the level of C-reactive protein and procalcitonin in the oral fluid of 23 volunteers (control group). The studies were started 2-3 days after the tooth extraction. Results. It was determined that before the operation the level of markers was statistically essentially increased in comparison with the control group in all patients with oroantral communications. In the first group C-reactive protein was increased 2,7 times, procalcitonin – 2,4 times. In the second group accordingly 3,1 and 3,3 times. By the 3rd day after the operation the concentration of markers increased more. However in the first group the C-reactive protein increased 3,3 times if compared with the control group and procalcitonin -3,6 times. In the second group – 8,6 and 8,4 times accordingly. By the seventh day after the operation the concentration of the inflammation markers decreased statistically essentially, but while in the 1st group it approached to the norm level, the second group revealed C-reactive protein staying 4,5 times higher than normal and procalcitonin was 4,7 times higher. Conclusion . The indicators of C-reactive protein and procalcitonin in the oral fluid of patients with oroantral communications are the markers of high sensitivity of the acute inflammation and they can be used either for the verification of the diagnosis or for the monitoring of the disease dynamics in post-operative period.