DYNAMICS OF HEMOREOLOGIC, BIOCHEMICAL AND IMMUNOLOGICAL INDICATORS IN PATIENTS WITH ACUTE HEMORRHOID THROMBOSIS UNDER THE INFLUENCE OF COMPLEX TREATMENT, INCLUDING PARENTERAL OZONE THERAPY

Abstract

The purpose of this work was to determine the effectiveness of acute hemorrhoid thrombosis treatment using the "Surgitron" device in combination with intravenous parenteral ozone therapy. Patients aged from 26 to 67 years, who were divided into groups, agreed to participate in the study. The main group included 34 (53.1%) patients who underwent treatment according to the generally accepted method with "Surgitron" device in combination with intravenous parenteral ozone therapy. The second group included 30 (46.8%) patients who underwent thrombectomy. To analyze the results, data on the duration of the pain syndrome, immunological changes and coagulogram parameters were used. Most pathological conditions are accompanied by inflammation, hypoxia, collateral thrombosis, activation of damage processes by lipid peroxidation products, disturbed cellular and humoral immunity, decreased local immune protection, increased incidence of inflammatory complications, changes in the hemostasis system, since damage to the blood vessel wall causes immediate vasoconstriction of both the damaged vessel itself and adjacent capillaries and arterioles, which leads to blood flow slowdown in the area of damage to the external and internal hemorrhoidal plexus. Under normal conditions, endothelial cells are responsible for the antithrombotic interaction between blood and tissues, maintaining the liquid state of the blood. They produce such anticoagulants as glucosoaminoglycans, heparin sulfates, thrombomodulin, nitric oxide, which promotes vasodilation, improves blood rheology. In our studies, the content of fibrinogen A, fibrinogen B (products of fibrin degradation), the prothrombin index decreased in patients, and the thrombin clotting time decreased. Damage to endothelial cells in the anal-hemorrhoidal zone is caused by endotoxins, leading to inflammatory edema, which results in intoxication. Ozone's detoxifying effect counter-balances these complications. This work presents and analyses the results of acute hemorrhoid thrombosis treatment with radio wave exposure, which provided non–contact incision and hemostasis of soft tissues by high frequency waves (3.8–4.0 Hz), in combination with intravenous ozone therapy to enhance the analgesic and anti-inflammatory effects characterized by oxygen supply and oxidation of mediators involved in passing nociceptive signals in the central nervous system. When carrying out the comparative analysis of the patients' treatment results, the use of ozone against the background of thrombectomy showed a positive effect.