Abstract
Dynamics of background levels of serum cytokines in children with atopic dermatitis with concomitant pathology of oral mucosa in the course of optimized complex therapy
Highlights
The purpose of the study was to study the dynamics of changes in the background level of serum IL-2, IL-4, IL-5, IL-10, IL-13, IFN- and TNF- in patients with various forms of AD with concomitant pathology of oral mucosa to find the optimal ways of using complex therapy
Serum IL-10 concentration levels were significantly increased in patients with IgE-dependent AD 71.0 (61.7-89.5)* compared with those in children with IgE-independent AD 62.8 (59.6-67.1)* (p
Serum IL-10 levels are capable of inducing both immunosuppressive processes and immunodeficiency states. This suggests that an i ncrease in IL-10 synthesis under the conditions of high IL-2 detected shifts cytokine synthesis in patients with IgE-dependent AD in the direction of cytokine production by regulatory lymphocytes. In support of this conclusion, in patients with children with IgE-dependent form of AD with concomitant pathology of oral mucosa in our study revealed a prolonged increase in serum concentration of IL-10 after combination therapy, which coincides with a significant improvement in clinical status
Summary
The purpose of the study was to study the dynamics of changes in the background level of serum IL-2, IL-4, IL-5, IL-10, IL-13, IFN- and TNF- in patients with various forms of AD with concomitant pathology of oral mucosa to find the optimal ways of using complex therapy
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