Abstract
Neuromuscular acetylcholine receptors (AChRs) mediate fast chemical synaptic transmission. Neurotransmitters bind to two sites in the α subunit extracellular domain (ECD) and trigger an isomerization that opens/closes the pore in the transmembrane domain (TMD). The TMD/ECD interface is a complex and important domain that links ‘binding’ and ‘gating’. We have examined one component of this interface, the pre-M1 region (linker connecting β10-strand of the ECD to M1 of the TMD) in both α and non-α subunits.
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