Abstract
Objective: The aim of this study was to evaluate thiol-disulphide homeostasis in patients with Multiple Sclerosis (MS) during attack and remission. Design and Methods: A total of 82 patients admitted to our clinic were divided into 2 groups according to whether they are having an attack or not. Peripheral blood samples were taken from all patients and their native thiol, disulphide and total thiol concentrations were measured by a newly developed automated method. In addition, their disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were calculated. Results: The average disulphide values, disulphide/native thiol and disulphide/total thiol ratios of the patients with MS who were having an attack were found to be significantly higher compared to those in remission (p = 0.001, p = 0.001, p = 0.001, respectively). Conclusion: Our results have shown that thiol-disulphide balance was shifted to the oxidative area during the relapse. These homeostasis parameters, which can be easily measured by this newly developed method at low costs, may be important in terms of showing the disease activity and presenting the underlying mechanisms of the disease.
Highlights
Multiple Sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), affecting more than 2 million people worldwide
We have examined the changes in thiol-disulphide homeostasis of MS patients in remission and relapse
Patients were considered to be in the relapse phase in the presence of newly emerged neurological signs and symptoms lasted more than 24 hours and in the presence of lesion with contrast observed in the MRI
Summary
Multiple Sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), affecting more than 2 million people worldwide. The disease affects the brain, spinal cord. How to cite this paper: Vural, G., Gumusyayla, S., Bektas, H., Deniz, O., Ergin, M. and Erel, O. (2016) Dynamic ThiolDisulphide Homeostasis in Patients with Multiple Sclerosis. Patients with MS exhibit variable clinical course. The majority has a relapsingremitting disease course characterized by intermittent neurological disturbance (episodes of acute worsening, relapse, attacks) followed by progressive accumulation of disability that affects social and occupational functioning. MS is the most common cause of non-traumatic disability in young adults [1] [2]
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