Abstract
A Highly stereoselective Gabriel reaction via dynamic kinetic resolution utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary was exploited. The reaction of tert-butyl (4 S)-1-methyl-3-(2-bromopropionyl)-2-oxoimidazolidine-4-carboxylate ( 2a) with potassium phthalimide at room temperature predominantly afforded tert- butyl (4S)-1- methyl-3-((2S)-2-( phthaloylamino)propionyl)-2-oxoimidazolidine-4-carboxylate ((S,S)- 5a) in a good yield which was derived to l- alanine derivative ( 7) by removal of the chiral auxiliary.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
