Abstract
AbstractBackgroundBrain network analysis from resting‐state functional MRI (fMRI) has helped us to understand cortical activity in dementia. Likewise, dynamic brain networks' analysis, which takes into account temporal fluctuations in the resting‐state fMRI signal, has helped to reveal patterns of activity, usually averaged out by the conventional functional network analysis. These patterns of activity, or dynamic networks, reveal transient (meta‐stable) dynamics. Dynamic functional networks analysis from fMRI data has shown a potential to unveil clinically relevant information.MethodResting‐state fMRI from 187 participants belonging to Alzheimer’s Disease (AD) and cognitively‐normal Healthy Elderly (HE) from the ADNI‐3 database were analysed. Functional network was constructed from fMRI signal of the 120 cortical and sub‐cortical regions of the Jülich Atlas for each participants, and averaged across the two study groups. Dynamic functional connectivity is calculated using sliding window approach and compared to conventional (‘static’) functional connectivity within each study group and between them.ResultSignificant differences when comparing AD with HE individuals were found in the dynamic, but not static functional networks. These differences were restricted to the white matter regions, and to the inferior and superior parietal, and somatosensory cortices.ConclusionOur results demonstrate the existence of common and distinct patterns of static and dynamic brain connectivity in HE and AD, which highlight the importance of including non‐stationary information into the brain network analysis in Alzheimer’s disease.
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