Abstract
Empirical rules based on tetranucleotide parameters were presented to predict the structural parameters twist ( Ω), roll ( ρ), tilt ( τ) and slide ( D y ). A statistical mechanical model was used to analyze the flexibility of the Escherichia coli genome. The replication terminus region displayed a low level of flexibility. A strong correlation can be seen between G+C content and flexibility. Average flexibilities in the coding regions were found to be significantly larger than those in non-coding regions. The flexible characteristics in the 5′-neighborhood of the coding regions and in three class sigma promoter sequences in the E. coli genome were also analyzed.
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