Dynamic changes of high-sensitive C-reactive protein and visfatin in patients with acute traumatic injury of brain

Abstract

Objective To observe the dynamic changes of high-sensitive C-reactive protein （hs-CRP） and visfatin in patients with acute traumatic injury of brain. Method A total of 120 patients with equal number in each gender （ n = 60） and with average age of （43.2 ± 6.2） years were admitted and treated by the neurosurgical department of ICU from August 2009 to June 2010. All patients were eligible to the diagnostic criteria of craniocerebreal injury. The clinical conditions of patients were assessed with Glasgow coma scale （C CS） at admission,and as per the scores of GCS, the patients were classified into mild degree （13- 15, n = 40）, moderate degree （9 - 12, n = 40） and severe degree （3 - 8, n = 40）. Another 60 subjects from those asking for health care by physical examination as control with equal number in each gender and their average age was （42.2±6.7） years.Blood samples were collected from fasted patients within 12 hours, 1d, 3d, 7d and 15 days after admission, and the levels of hs-CRP and visfatin in peripheral blood were detected. Results The levels of hs-CRP and visfatin were significantly higher in brain injury group than those in control group on the admission day （both P 〈 0.01 ）,and they both had positive relationships with severity of injury. The level of hs-CRP increased to peak on the first day of admission and visfatin increased to the peak on the 3rd day after admission. There was a correlation between levels of hs-CRP and visfatin （ r = 0.63, P 〈 0.01 ）. Conclusions hs-CRP and visfatin levels are related to the severity of acute traumatic injury of brain. Key words: Traumatic brain injury; High-sensitive C-reactive protein（hs-CRP） ; Visfatin