Abstract
DNA methylation is one of the most common epigenetic alterations, providing important information regarding cancer risk and prognosis. A case-control study (423 breast cancer cases, 509 controls) and a case-only study (326 cases) were conducted to evaluate the association of DUSP1 promoter methylation with breast cancer risk and clinicopathological characteristics. No significant association between DUSP1 methylation in peripheral blood leukocyte (PBL) DNA and breast cancer risk was observed. DUSP1 methylation was significantly associated with ER/PR-negative status; in particular, triple-negative breast cancer patients showed the highest frequency of DUSP1 methylation in both tumour DNA and PBL DNA. Soybean intake was significantly correlated with methylated DUSP1 only in ER-negative (OR 2.978; 95% CI 1.245–7.124) and PR negative (OR 2.735; 95% CI 1.315–5.692) patients. Irregular menstruation was significantly associated with methylated DUSP1 only in ER-positive (OR 3.564; 95% CI 1.691–7.511) and PR-positive (OR 3.902, 95% CI 1.656–9.194) patients. Thus, DUSP1 methylation is a cancer-associated hypermethylation event that is closely linked with triple-negative status. Further investigations are warranted to confirm the association of environmental factors, including fruit and soybean intake, irregular menstruation, and ER/PR status, with DUSP1 methylation in breast tumour DNA.
Highlights
Inactivation and gene silencing, and contributes to the tumorigenesis of several cancers[16,17,18]
We explored the correlation between clinicopathological characteristics and DUSP1 methylation in both tumour DNA and peripheral blood leukocyte (PBL) DNA, as well as the effect of environmental factors on DUSP1 methylation in tumour tissue DNA
We first explored the value of DUSP1 methylation in PBL DNA for the risk assessment of breast cancer, but we failed to find any association between DUSP1 methylation in PBL DNA with breast cancer risk, or for the interactive effects of DUSP1 methylation and environmental factors
Summary
Inactivation and gene silencing, and contributes to the tumorigenesis of several cancers[16,17,18]. Ji-Yeob et al found that leukocyte DNA hypomethylation is independently associated with the development of breast cancer[24]. Peripheral blood leukocyte (PBL) DNA might be a potential surrogate biomarker for cancer risk assessment. Different tissues may exhibit different responses to environmental factors, and methylation status in leukocytes may not fully reflect the changes in the target tissue[29]. Given the lack of research on DUSP1 methylation in breast cancer in epidemiological studies, we first investigated the association between DUSP1 methylation in PBL DNA, interactions with environmental factors, and breast cancer risk. We explored the correlation between clinicopathological characteristics and DUSP1 methylation in both tumour DNA and PBL DNA, as well as the effect of environmental factors on DUSP1 methylation in tumour tissue DNA
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
