Abstract
ABSTRACT IT IS a well-known fact that the basic function of thyroid hormone in vertebrates is to regulate the rate of energy exchange (oxidative metabolism). It is also widely known that thiourylenes such as thiouracil inhibit in vivo synthesis of thyroid hormone, thus causing a state of hypothyroidism. In spite of these well-established relationships, there have been several disagreements apparent in various reports concerning the metabolic effects of thyroprotein and thiouracil in the fowl. Sulman and Perek (1947) stated that thiouracil feeding lowered the basal metabolic rate (MR) in White Leghorn hens, but their data do not seem to justify this conclusion. Romijn (1950) reported that 6-methyl-2-thiouracil depressed resting metabolism in 10-week-old and 3-month-old chickens, but not in birds which were five months old. Singh and Shaffner (1950) concluded that oxygen consumption in young, fasting chickens was lowered after thiouracil feeding and raised by thyroprotein in the diet, and similar results . . .
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