Abstract
In this study, we designed, synthesized, and characterized a novel pH- and redox responsive nanoparticle system for the enhanced spatial delivery of hydrophobic drugs. A statistical copolymer library of pyridyldisulfide ethyl methacrylate (PDSM) with different compositions of 2-((tert-butoxycarbonyl)(2-((tert-butoxycarbonyl)amino)ethyl)amino)ethyl methacrylate (BocAEAEMA) was synthesized using the reversible addition–fragmentation chain transfer (RAFT) polymerization process. The controlled nature of the radical polymerization was demonstrated by a kinetic study. The Boc-groups were cleaved to obtain the desired amino functional copolymers. Nanoparticles were prepared by nanoprecipitation and characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Differently sized nanoparticles that have monomodal size distributions ranging from 50 to 460 nm with positive ζ-potential values were obtained by varying initial conditions of the formulat...
Published Version
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