Abstract
A novel affinity biosensor is proposed based on the hybrid plasmonic platform. The proposed biosensor benefits from the high sensitivity of the surface plasmon resonance (SPR), while at the same time, it is capable of performing measurements in both the TM and TE polarizations (p- and s-polarizations). Unlike the conventional SPR biosensors, the polarization diversity of the hybrid sensor allows for decoupling of the bulk index variations in the fluidic channels (due to variations in concentration, decomposition, temperature, and so on) from the surface properties of the attached molecules. Compatibility of the proposed hybrid plasmonic biosensor with standard Si-processing techniques and the simplicity of its design are other advantages of the sensor which makes its fabrication straightforward. The best figure of merit for the biosensor is defined based on the minimum detection limit and a genetic algorithm is used to optimize the device. A method of de-convolving the surface and bulk effects is also discussed.
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