Dual compound loaded chitosan nanoparticles: synthesis and optimization

Abstract

Event Abstract Back to Event Dual compound loaded chitosan nanoparticles: synthesis and optimization Nurhanisah Othman1, Mas Jaffri Masarudin2, 3, Cha Yee Kuen2, 3, Nurul Azira Dasuan1, Luqman Chuah Abdullah4 and Siti Nurul Ain Md Jamil1* 1 Department of Chemistry, Faculty of Science, Putra Malaysia University, Malaysia 2 Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Putra Malaysia University, Malaysia 3 MAKNA Cancer Research, Institute of Bioscience, University Putra Malaysia, Malaysia 4 Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, Malaysia Introduction: Chitosan nanoparticles (CNP) have been tremendously studied for its excellent property as drug carrier. However, its hydrophilicity makes it more selective to certain pharmaceutical products. Encapsulation of both hydrophilic l-ascorbic acid (LAA) and hydrophobic thymoquinone (TQ) in CNP were investigated to augment its potential in delivering compounds. Method: CNP loaded with antioxidant LAA and TQ were synthesized via harmless ionic gelation routes. They were then characterized by using Fourier-Transform Infrared Spectroscopy (FTIR), nanosizer, UV-vis spectrophotometer and Field Emission Scanning Electron Microscope (FESEM). Result: The optimum CNP-LAA-TQ size produced was 141.5 ± 7.8 nm. The encapsulation efficiency of CNP-LAA-TQ was 22.8 ± 3.2 % for LAA and 35.6 ± 3.6 % for TQ. Conclusion: The incorporation of hydrophilic LAA and hydrophobic TQ in a single CNP organization contributes in the advancement of multidrug therapy, especially in treating tuberculosis and cancers. The emergence of this dual compound nanoparticles is hoped to solve the issue of multitudinous potent drugs with low systemic uptake. Keywords: antioxidant, Chitosan, Hydrophobic-hydrophilic, Ionic gelation, Nanoparticles Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Oral Presentation Topic: Miscellaneous Citation: Othman N, Masarudin M, Kuen C, Dasuan N, Abdullah L and Md Jamil S (2019). Dual compound loaded chitosan nanoparticles: synthesis and optimization. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00040 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Siti Nurul Ain Md Jamil, Department of Chemistry, Faculty of Science, Putra Malaysia University, Serdang, Selangor, 43400, Malaysia, ctnurulain@upm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nurhanisah Othman Mas Jaffri Masarudin Cha Yee Kuen Nurul Azira Dasuan Luqman Chuah Abdullah Siti Nurul Ain Md Jamil Google Nurhanisah Othman Mas Jaffri Masarudin Cha Yee Kuen Nurul Azira Dasuan Luqman Chuah Abdullah Siti Nurul Ain Md Jamil Google Scholar Nurhanisah Othman Mas Jaffri Masarudin Cha Yee Kuen Nurul Azira Dasuan Luqman Chuah Abdullah Siti Nurul Ain Md Jamil PubMed Nurhanisah Othman Mas Jaffri Masarudin Cha Yee Kuen Nurul Azira Dasuan Luqman Chuah Abdullah Siti Nurul Ain Md Jamil Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.