Abstract
Magnetic nanoparticles used in biomedicine require surface modification ensuring formation of non-toxic, biocompatible nanoparticles. Among the great variety of available biocompatible polymers, a hydrophilic polymer polyethylene glycol (PEG) that has the ability to prevent protein adsorption was chosen for coating prepared magnetite nanoparticles. The aim of this work was to use differential scanning calorimetry (DSC) for studying the adsorption of PEG of different average molecular weights and different feed weights on magnetite nanoparticles and to estimate the maximal amount of PEG adsorbed on the magnetite nanoparticles. The increasing PEG molecular weight has a tendency to the decrease in the maximal feed weight ratio of PEG to magnetite in the studied complex systems. The morphology observed by scanning electron microscopy showed that all studied systems of magnetic particles coated with PEG had almost spherical shape.
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