Abstract
1. 1. The widespread use and abuse of psychoactive compounds have increased the reports of drug-induced perceptual distortions and have generated an interest in the occurrence of such phenomena in non-human species. 2. 2. In a paradigm similar to human timing procedures, water-deprived rats were differentially reinforced for depressing a lever for 4.5 to 5.5 sec. 3. 3. Administration of amphetamine and tetrahydrocannabinol resulted in premature release of the lever (“short” errors); lysergic acid diethylamide and chlorpromazine prolonged depression of the lever beyond the required interval (“long” errors). 4. 4. The procedure employed appears sensitive to drug-induced shifts in timing behavior and permits direct comparison between the results of timing experiments with lower animals and the data obtained from the temporal production experiments commonly used with humans.
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