Drug–zein@lipid hybrid nanoparticles: Electrospraying preparation and drug extended release application

Abstract

The reasonable selection and elaborate conversion of raw materials into desired functional products represent a main topic in modern material engineering. In this study, zein (a plant protein) and lipids (extracted from egg yolk) are converted into a new type of drug–polymer@lipid hybrid nanoparticles (HNPs) via modified coaxial electrospraying. Tamoxifen citrate (TC) is used as a model anticancer drug to prepare TC–zein monolithic nanocomposites (MNCs) via traditional blended electrospraying; these MNCs are then used for comparison. Modified coaxial electrospraying is a continuous and robust process for the preparation of solid particles because of the action of unsolidifiable shell lipid solutions. HNPs have a round morphology with clear core–shell nanostructures, whereas MNCs have an indented flat morphology. Although both hold the drug in an amorphous state because of the fine compatibility of TC and zein, HNPs demonstrate a better sustained release of TC compared with MNCs in terms of retarding initial burst release (6.7 %±2.9 % vs. 37.2 %±4.3 %) and prolonged linear release period (20.47 h vs. 4.97 h for releasing 90 % of the loaded drug). Mechanisms by which the shell’s lipid layer adjusts the release behavior of TC molecules are proposed. The present protocol based on coaxial electrospraying shows a new strategy of combining edible protein and lipids to fabricate advanced functional nanomaterials.