Abstract
The drug-transporter gene ABCB1 polymorphism (C to T) at position 3435 was typed in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 controls without epilepsy, in a study at the Institute of Neurology, London, UK.
Highlights
The drug-transporter gene ABCB1 polymorphism (C to T) at position 3435 was typed in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 controls without epilepsy, in a study at the Institute of Neurology, London, UK
The C polymorphism was overrepresented among drugresistant as compared with drug-responsive patients (p=0.008)
Multidrug-resistance proteins such as ABCB1 are important in the development of refractory epilepsy, and over-expression of these proteins has been demonstrated in the temporal-lobe tissue from patients with epilepsy
Summary
The drug-transporter gene ABCB1 polymorphism (C to T) at position 3435 was typed in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 controls without epilepsy, in a study at the Institute of Neurology, London, UK. Compared with the drug-responsive patients, those with drug-resistant epilepsy were more likely to have the CC genotype at ABCB1 3435 than the TT genotype (p=0.006). (Siddiqui A, Kerb R, Weale ME, et al Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
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