Abstract
In a 12-month nationwide study on the prevalence of drug-resistant tuberculosis (TB) in Lebanon, we identified 3 multidrug-resistant cases and 3 extensively drug-resistant TB cases in refugees, migrants, and 1 Lebanon resident. Enhanced diagnostics, particularly in major destinations for refugees, asylum seekers, and migrant workers, can inform treatment decisions and may help prevent the spread of drug-resistant TB.
Highlights
In a 12-month nationwide study on the prevalence of drug-resistant tuberculosis (TB) in Lebanon, we identified 3 multidrugresistant cases and 3 extensively drug-resistant TB cases in refugees, migrants, and 1 Lebanon resident
Results of genotypic analysis of the 3 MDR TB isolates by Deeplex-MycTB were consistent with phenotypic profiling overall, considering that a rare F129S mutation in katG was previously described in association with isoniazid resistance [11], along with other well-established mutations
Conclusions the prevalence of rifampin-resistant TB estimated in Lebanon is relatively low (2.8%), identification of XDR TB and MDR TB cases, including TB strains with strong epidemic potential and complex resistance patterns, calls for sustained diagnosis of MDR TB
Summary
In a 12-month nationwide study on the prevalence of drug-resistant tuberculosis (TB) in Lebanon, we identified 3 multidrugresistant cases and 3 extensively drug-resistant TB cases in refugees, migrants, and 1 Lebanon resident. Rifampin resistance was detected among 7/250 (2.8%) patients, concordantly with Xpert testing results for all cases (Table 1). §Resistant to RIF, INH, EMB, SM, amikacin and kanamycin, and levofloxacin (representing all tested drugs for MDR and XDR isolates).
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