Abstract
In order to further analyze the relationship between the coating mechanism of microorganisms and their drug resistance, a study of ocular bacterial drug resistance considering the coating mechanism of microorganisms was proposed. Firstly, the mechanism of drug resistance was analyzed, and on this basis, the experimental study was carried out. Staphylococcus aureus DH5 with RP4 was used as the control α( R) Objective to investigate the relationship between drug-resistant bacteria and coating mechanism in the cross genus conjugation system of Pseudomonas aeruginosa PAOi and donor bacteria. The conclusion is that: under the condition that the horizontal transfer of drug-resistant genes between transgeneric bacteria in biofilm is inhibited, the frequency of drug-resistant gene conjugation and transfer gradually decreases, and the inhibition of the formation of drug-resistant bacterial biofilm will directly lead to the decrease of bacterial drug resistance.
Highlights
Whether it is a common antimicrobial or a new type of antimicrobial, the resistance of bacteria to them is increasing.Firstly, for example, in 1939, the treatment of pneumonia with penicillin of 80000 international units had good effect
Both Ca HSL and 3-oxo-ci2-hsl are key signaling molecules in the quorum sensing and effector system of Pseudomonas aeruginosa. Their synthesis is controlled by rhli and Lasi in PAO1 quorum sensing and effector system, respectively
The binding and transfer of RP4 plasmid was considered to occur in the biofilm
Summary
Whether it is a common antimicrobial or a new type of antimicrobial, the resistance of bacteria to them is increasing.Firstly, for example, in 1939, the treatment of pneumonia with penicillin of 80000 international units had good effect. In 1970, 10 times more penicillin was needed to get the same effect. By 100 times of penicillin in the early 21st century can it be effective [1,2]; Secondly acterial resistance can increase the mortality and incidence of infectious diseases. With the widespread use of antimicrobial agents, bacteria will produce resistance to each antimicrobial drug, which is the general rule of nature [7,8]. The mechanism of bacterial resistance is a complex and dynamic process, which is regulated by many aspects, including the function, heredity and environmental factors of bacteria [9,10]. To understand the research status of drug resistance mechanism is of great significance to prevent and control bacterial resistance
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