Drug resistance of Gram-negative bacteria from the 264th hospital of PLA

Abstract

Objective To investigate the distribution and drug resistance of Gram-negative bacterial in the recent year in the 264th hospital of PLA and provide the basis for clinical use of the drugs reasonably.Methods Using ATB drug seneitive batten and K-B method for the drug susceptibility test and using WHONE software analysis of bacterial drug resistance by French BioMerieux ATB expression system.Results One thousand strains of Gram-negative bacteria mainly originates from the sputum,wound exudate,urine and blood,including Pseudomonas aeruginosa,Bauman Acinetobaeter,Escherichia coli and Pneumonia Cray Borrelia bacteria,respectively 54.4％,28.3％,23.0％ and 12.3％.The detection rate of Escherichia coil and Bacillus pneumonia Cray which was production of ESBLs were 54.5％ and 49.6％,while the higher resistance rates of the commonly used Penicillin,and the minimum resistance rates of Imipenem and Meropenem were respectively 2.5％ and 3.9％ by contrary.Among Pseudomonas aeruginosa,the resistance rates of Ceftazidime and Imipenem were 35.2％ and 48.0％.And for other antimicrobial drug resistance rate in 50.0％ above,while the Bauman Acinetobacter,the resistance rates of Cefoperazone/Sulbactam was 38.3％ and to other antimicrobial drug resistance rate in 80.0％ above.Conclusions The mainly Gram-negative bacterial of nosocomail infection which are Pseudomonas aeruginosa,Bauman Acinetobacter,Escherichia coli and Pneumonia Cray.Among Bauman Acinetobacter,emergence of extensively drugresistant.It is very important for rational use of antimicrobial drugs,enhance detection of bacterial resistance and drug-resistant control. Key words: Bacterial resistance; Gram-negative bacteria; Antibacterial drug