Drug release kinetics of capsule shells from seaweed carrageenan extract (Eucheuma cottonii) and potato starch as a gelling agent

Abstract

BackgroundCapsules are created to put a drug or active pharmaceutical ingredient in an elegant, odorless, tasteless, easy-to-swallow and to-fill shell commonly produced from gelatin. Therefore, carrageenan is one of the other natural ingredients that can replace gelatin. This study aims to make capsule shells from carrageenan seaweed (Eucheuma cottonii) with variations in carrageenan composition and temperature using potato starch as a gelling agent with the addition of PEG as a plasticizer and to determine the kinetics model of the drug release system from the capsules that have been made.ResultsIn the research there are two variations namely composition and temperature. The capsule shell dissolution test results were calculated using kinetic models of order 0, order 1, Higuchi, and Korsmeyer-Peppas. The result on zero order is that at the C composition and temperature 55 ºC variations obtained the reaction rate constant (k) are 1.05 and 1.27 min respectively. While in first order obtained the reaction rate constant of 4.59 × 10–2 and 2.06 × 10−2 min−1 respectively at variations in capsule D composition and temperature of 60ºC. In the Higuchi model, the correlation coefficient for composition variation is better than temperature variation of 0.92. In the Korsmeyyer-Peppas model, the value of reaction rate constant (k) at composition C and temperature of 55 ºC variations are 1.41 × 10–2 and 9.49 × 10−3 min−n.ConclusionsThe Korsmeyyer–Peppas kinetic model is suitable for illustrating the drug release kinetics of capsule shells from seaweed carrageenan extract (Eucheuma cottonii) and potato starch as a gelling agent.