Abstract
Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs.
 Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS.
 Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations.
 Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.
Highlights
An ideal drug delivery system aims to deliver the drug, selectively and effectively, to the site of action in the body
This has increased the attention towards the continuous development and improvement of drug delivery systems, capable to enhance the solubility of poorly soluble drugs; enhancing the drug bioavailability and therapeutic efficacy [1]
Meola et al [13] used Capmul® MCM in the preparation of silica-lipid hybrid microparticles to improve the dissolution and oral delivery of simvastatin. 2-hydroxyethyl methacrylate (HEMA) represents one of the most commonly used synthetic monomers for the preparation of crosslinked polymers and it has been widely used in many pharmaceutical applications such as soft contact lenses [14] and drug carriers [15]
Summary
An ideal drug delivery system aims to deliver the drug, selectively and effectively, to the site of action in the body. The poor bioavailability represents a major issue for new drug entities as around 60% of these new drugs are reported to have bioavailability issue due to solubility problems This has increased the attention towards the continuous development and improvement of drug delivery systems, capable to enhance the solubility of poorly soluble drugs; enhancing the drug bioavailability and therapeutic efficacy [1]. Capmul® MCM products have been widely employed in skin care products and food industries such as; ice creams, bakery, beverages, chewing gums and confectionery They are obtained via direct esterification of glycerin with vegetable sourced octanoic and decanoic acids. The main objective of this study was to develop a drug delivery system, based on poly (2-hydroxyethyl methacrylate) polymer with different concentrations of Capmul® MCM C8, prepared using a free radical polymerization method as a promising system to control and enhance the release of poorly water soluble drugs. Swelling studies were performed for the produced carriers and in vitro release studies were performed to study the effect of changing the concentration of Capmul® MCM C8 on the release profiles of the model drug
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