Abstract
Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biobased (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, mainly class B type I (i.e., SR-BI), and crosses the blood-brain barrier.
Highlights
Vascular brain lesions are very common in people over 70-years-old, and recent reviews [1,2] provide much evidence that a large proportion of dementia cases may be attributable to cerebrovascular disease [3,4]
The cardiovascular risk factors for this disease trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption
Past studies (e.g., [69,70]) have shown that low-grade inflammation and endothelial dysfunction contribute to reduced information processing speed and executive functioning in an older population. These interacting processes involve pathophysiological cascades which lead to neuronal Ca2+ increase, neurodegeneration, gradual cognitive/memory decline, and eventually dementia
Summary
Vascular brain lesions are very common in people over 70-years-old, and recent reviews [1,2] provide much evidence that a large proportion of dementia cases may be attributable to cerebrovascular disease [3,4]. Alzheimer's disease, Blood-brain barrier, Cognitive impairment, Drug targeting, Lipid cubic phases, Nanoemulsion, Scavenger receptors, SR-BI, Vascular dementia
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