Abstract
Immunological tolerance to sheep's red cells was induced in mice of various strains (CBA, C57BL/6, CC57BR, C3H, DBA/2) by combined injection of a large dose of antigen and cyclophosphamide into the animals. After a test injection of erythrocytes the number of 19S-antibody-forming cells was determined in the spleens of the mice by the local hemolysis in gel method. The degree of tolerance developing was shown to depend on the animals' genotype, and mice of strain DBA/2 were found to be the most sensitive to its induction. No correlation was found between the level of immunological reactivity to sheep's red cells in intact mice of different strains and the degree of its inhibition as a result of the induction of tolerance.
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