Abstract
Experiments were conducted to determine the relative importance of hyperthermia as a factor influencing the toxicity of amphetamine in aggregated and isolated mice. The ability of several agents to interfere with the hyperthermic response to amphetamine was compared with their ability to alter the incidence of lethality to this drug. It was evident that there was no direct relationship between the ability of the selected drugs to prevent the body temperature of mice from reaching the maximum temperature level of amphetamine-treated controls and their ability to protect mice from amphetamine-induced lethality. It was concluded that hyperthermia does not, in itself, appear to be the causative factor for the increased incidence of mortality to amphetamine observed in aggregated versus isolated mice.
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