Abstract
The possibility that the high level of acetylcholine (ACh) in the corneal epithelium is associated with sensory mediation was investigated using the drugs hemicholinium-3 (HC-3), triethylcholine (TECh) and trans-4-(1-naphthylvinyl) pyridine hydrochloride (NVP). None of these drugs when topically administered to the rabbit cornea affected the corneal ACh content, as measured by bioassay. Administered by intraocular injection into the aqueous humour, HC-3 produced no ACh depletion, despite a 60 per cent reduction in 14C-choline uptake from the aqueous humour. Intraocularly injected TECh produced a transient depletion of corneal ACh, while NVP caused a reduction to 38 per cent of the control level. In no case did these drugs cause abolition of the corneal reflex. Experiments using topical application of neostigmine in conjunction with ACh depletion by NVP suggest the possible existence of more than one pool of ACh in the rabbit corneal epithelium
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
