Abstract
Because of their specificity, sensitivity, rapidity and convenience, drug-specific immunoassays are now widely used both in clinical and investigative laboratories. Drug immunoassays are of clinical value in the determination of appropriate dosage schedules with certain drugs and in the documentation of recent ingestion of other drugs, particularly certain drugs of abuse. Immunoassays have already been of investigative value in studies of the bioavailability, absorption, metabolic degradation and excretion of several drugs. This review deals with the synthesis and characterization of drug-protein conjugates, immunization with drug-protein conjugates, the detection and immunological characterization of drug-specific antibodies, the use of drug-specific antibodies in the development of immunoassays, general applications of drug immunoassays and, finally, individual descriptions of currently available drug immunoassay methods.
Published Version
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