Drug Delivery System That Self-Emulsify: Transportation of Drug From Gut to Target Organs

Abstract

Microemulsions are highly popular for their specific uses, including vivid applications and this is due to their special properties, which include very high interfacial interactions with demonstrated stability from a thermodynamics point of view, and on the other hand, also very low interfacial tension, which is required to solubilize highly immiscible dispersions. This review’s goal is to briefly outline potential uses of micro-emulsion systems, their uses, limitations and possible in-vitro and in-vivo techniques. To characterise such dispersion systems, it is commonly known that adding the right surfactant or surfactant mixture can combine large amounts of two non-dissolving-target liquids, such as water and oil, into a single phase that is macroscopically homogeneous but microscopically heterogeneous. Owing to the advantages of lymph drug delivery, the drug-lipid conjugates, when they enter the lymph route, become an ideal approach for enhancing the absorption of such drugs to combat metastatic cancers of the lymph nodes and their drainage to specific organ systems where the cancer is already spread. As the route of lymph delivery is important where a tumor has already been cancerous, this formulation approach has distinct opportunities to transport needy molecules to cancerous sites in various organs, which also includes the lymph nodes. This review, particularly, lays more stress on an overview of microemulsions in general, the in-vivo and in-vitro characterization methods and potential applications related to target drug delivery via the lymphatic circulatory system.