Abstract
Droplet microfluidics technology is recently a highly interesting platform in material fabrication. Droplets can precisely monitor and control entire material fabrication processes and are superior to conventional bulk techniques. Droplet production is controlled by regulating the channel geometry and flow rates of each fluid. The micro-scale size of droplets results in rapid heat and mass-transfer rates. When used as templates, droplets can be used to develop reproducible and scalable microparticles with tailored sizes, shapes and morphologies, which are difficult to obtain using traditional bulk methods. This technology can revolutionize material processing and application platforms. Generally, microparticle preparation methods involve three steps: (1) the formation of micro-droplets using a microfluidics generator; (2) shaping the droplets in micro-channels; and (3) solidifying the droplets to form microparticles. This review discusses the production of microparticles produced by droplet microfluidics according to their morphological categories, which generally determine their physicochemical properties and applications.
Highlights
Monodisperse microparticles and nanoparticles with uniform sizes and morphologies are used in bio-pharmaceuticals [1,2], drug delivery applications [3,4], electro/optic devices [5,6] and catalysis [7,8,9] because of their unique properties
Droplet microfluidics microfluidicscan canprovide provide environments with properties of exceptional control and stability, whichwhich can be used for performing microparticles synthesis with with unique properties
We reviewed the different microfluidic systems for controlling droplet formation, the influencing for regulating droplet size and structure, and droplets solidification methods according to different factors for regulating droplet size and structure, and droplets solidification methods according to materials
Summary
Monodisperse microparticles and nanoparticles with uniform sizes and morphologies are used in bio-pharmaceuticals [1,2], drug delivery applications [3,4], electro/optic devices [5,6] and catalysis [7,8,9] because of their unique properties. The superior properties of droplet microfluidics are advantageous for precise microparticle more flexibility because only the device structures need to be changed to produce complex structure manufacturing, especially when used as templates to prepare microparticles and nanoparticles with droplets, such as single-emulsions, double-emulsions and multi-emulsions [37,38]. Because a single nanoparticles chemical,for photochemical or and physical methods [39] This reviewcan discusses recent for emulsion can be abytemplate solid spheres, double or multi-emulsions be templates advances in microparticle and nanosphere fabrication with droplet microfluidics. This review provides a general background to those new to structures, and focused on how the emulsion droplets evolved into various structures and morphologies, droplet microfluidics. This review provides a general background to those new to droplet microfluidics
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