DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery.

Carla Barbosa Nonino,Caroline Rossi Welendorf,Mariana Barato,Maysa Araújo Ferreira-Julio,Doroteia Rossi Silva Souza,Marcela Augusta De Souza Pinhel,Flávia Campos Ferreira,Wilson Salgado Junior,Carolina Ferreira Nicoletti,Ligia Moriguchi Watanabe,Natalia Yumi Noronha,Heitor Bernardes Pereira Delfino

doi:10.1007/s40519-021-01290-6

Abstract

The aim of this study was to analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes with BED in patients with weight regain in the postoperative period of bariatric surgery. One hundred and seventy-seven individuals who underwent bariatric surgery with weight regain were evaluated and divided into two groups according to the BED diagnostic. The individuals were submitted to an anthropometric evaluation, analysis of the presence of BED using a validated questionnaire, and blood collection for genotyping of the polymorphisms rs6265 (BDNF) and rs1800497 (DRD2) by real-time polymerase chain reaction (RT-PCR). The presence of wild-type alleles for rs1800497 (CC) and rs6265 (GG) was more frequent in patients without BED. Nevertheless, the presence of one or two variant alleles for rs1800497 (CT + TT) and rs6265 (GA + AA) was more frequent in patients with BED. The combination of the two studied SNPs prevailed in patients with BED. The presence of allele frequency of rs1800497 SNP in the DRD2 gene and rs6265 SNP in the BDNF gene, isolated and/or combined, indicated an additional risk for the development of BED in patients with obesity, especially in the context of weight regain. III (evidence obtained from the case-control analytic study).

Highlights

Binge eating disorder (BED) is characterized by recurrent episodes of binge eating at least once a week for three months, associated with lack of control and pronounced suffering
The percentage of weight regain was similar for the BED group (22.02%) and the group without BED (25.93%) (p = 0.471)
We found that the CC genotype, the homozygous wild type, was more frequent in patients without BED (67.5%) when compared to the group with BED (44.7% p = 0.004); the presence of the one or two variant alleles (CT + TT) was more frequent in the BED group (55.3%) compared to the group without BED (32.5%) (p = 0.004), indicating a possible risk for BED related with this polymorphism

Summary

Introduction

Binge eating disorder (BED) is characterized by recurrent episodes of binge eating at least once a week for three months, associated with lack of control and pronounced suffering. Since BED is not usually associated with compensatory behaviors, such as fasting and excessive exercise after eating, BED individuals are frequently obese [1, 4,5]. The prevalence of BED in individuals with obesity is about 5 to 30% [2,3]. BED etiology is multifactorial, involving psychological, sociocultural, and, more recently, genetic factors. SNPs are not the only determinant factors, they indicate a genetic predisposition for the individual to develop eating disorders [6]

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