Gene-gene interaction between genes of brain-derived neurotrophic factor and dopamine D1receptor in schizophrenia

Abstract

Objective To explore the impact of brain-derived neurotrophic factor (BDNF) on the contribution of dopamine D1receptor (DRD1) to schizophrenia. Methods One single nucleotide polymorphism (SNP) (Val66Met,rs6562) within BDNF gene and five tag-SNPs (rs4532,rs5326,rs2168631,rs6882300 and rs267418) within DRD1 gene were genotyped in 340 schizophrenic patients and 375 healthy controls.The gene-gene interaction between BDNF and DRD1 was analyzed by Multifactor Dimensionality Reduction (MDR) software. Results There were no significant differences on the frequencies of the genotypes and alleles of the six SNPs between patients and controls (P s>0.0083).MDR revealed that the significance were shown in patterns with 2 SNPs (rs6265-rs5326;OR=1.83,95% CI:1.33-2.53,χ2=13.91,P=0.0002),3 SNPs (rs6265-rs4532-rs6882300;OR=2.06,95% CI:1.53-2.78,χ2=22.73,P<0.0001) and 4 SNPs (rs6265-rs5326-rs2168631-rs6882300;OR=2.85,95% CI:2.09-3.89,χ2=44.99,P<0.0001). Conclusion There may be the gene-gene interaction between genes of BDNF and DRD1 in schizophrenic patients.BDNF may play an important role in the contribution of DRD1 to the development of schizophrenia. Key words: Schizophrenia; Brain-derived neurotrophic factor; Receptors,dopamine D1; Gene-gene interaction