İdrar yolu enfeksiyonlarından izole edilen Pseudomonas Aeruginosa’larda antibiyotik direnci.

Abstract

Aim: Pseudomonas aeruginosa infections have become a major problem in the world and in our country. P. aeruginosa is often encountered as a nosocomial infection. Anatomical defects of the urinary tract or urinary tract interventional applications increases the development of P. aeruginosa infection. Urinary tract infection can also lead to the development of life-threatening sepsis. In this study, we investigated the change of antibiotic resistance profiles of P.aeruginosa strains isolated from hospitalized patients as a urinary tract infection by the years. Material and Methods: This study includes 103 P. aeruginosa strains isolated from hospitalized patients with urinary tract infection between the years 2008-2012. Identification and antibiotic susceptibility studies of the strains were performed by conventional methods and automated systems (Phoenix, BD, USA). Results: Maximum resistance was shown to ceftazidime (85.4%), and Piperacillin/Tazobactam (86.6%). Moderate resistance was observed against cefepime (46.7%) and levofloxacin (41.8%). However, least number of isolates showed resistance against carbapenems (20.4%). P. aeruginosa isolates from three urinary tract infection patients with similar resistance patterns were also isolated from their blood cultures.Therefore the isolates were evaluated as sepsis factors. Conclusion: This s tudy showed that most P. aeruginosa strains causing urinary tract infections gain rapidly increasing resistance to the majority of antibiotics used in the treatment. Keywords: Urinary tract infections, Pseudomonas aeruginosa, Antibiotic resistance rates, Urosepsis