Abstract
Pseudomonas aeruginosa is a frequent human pathogen that increasingly causes chronic infections of nonhealing wounds. Here we present the 6.8 Mb draft genome of strain WS394, a multidrug-resistant chronic ulcer isolate that exhibited outstanding high cell cytotoxicity despite defective secretion of exotoxin U, suggesting a habitat-dependent adaptation process.
Highlights
P. aeruginosa genomes range from 5.8 to 7.3 megabases (Mb) in size, with GϩC contents of about 66%
exotoxin U (ExoU) is a potent cytotoxin with phospholipase A2 activity causing rapid necrotic death in many cell types that may lead to epithelial barrier injury, inhibition of the innate immune response, and impaired wound repair
ExoU-secreting, and typically highly virulent, strains were found to be less prevalent in human infections [3]
Summary
P. aeruginosa genomes range from 5.8 to 7.3 megabases (Mb) in size, with GϩC contents of about 66% (http://www .pseudomonas.com). Pseudomonas aeruginosa is a prevalent Gram-negative human pathogen that causes a variety of acute and chronic infections affecting predominantly immunocompromised hosts. Chronic infections such as cystic fibrosis (CF) lung infection due to P. aeruginosa are often difficult to treat due to several phenotypic adaptations of this pathogen, including multiple antibiotic resistances [1].
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