Abstract
ABSTRACTTyphoid is endemic in developing countries. We report here the first draft genome sequence of a Salmonella enterica serovar Typhi clinical isolate from Pakistan exhibiting resistance to cefepime (a fourth-generation cephalosporin) and fluoroquinolone antibiotics, two of the last-generation therapies against this pathogen. The genome is ~4.8 Mb, with two putative plasmids.
Highlights
Typhoid fever is one of the leading causes of mortality due to infectious diseases in developing Asian and African countries
We performed whole-genome sequencing of a multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi clinical isolate obtained from a patient admitted to a tertiary care hospital in Rawalpindi, Pakistan [3]
The isolate was phenotypically resistant to a fourth-generation cephalosporin and several fluoroquinolones
Summary
Typhoid fever is one of the leading causes of mortality due to infectious diseases in developing Asian and African countries. We performed whole-genome sequencing of a multidrug-resistant Salmonella enterica subsp. Enterica serovar Typhi clinical isolate obtained from a patient admitted to a tertiary care hospital in Rawalpindi, Pakistan [3]. The isolate was phenotypically resistant to a fourth-generation cephalosporin (cefepime) and several fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin). Whole-genome sequencing (WGS) was carried out to identify the resistance determinants carried by this S.
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