Clinical characteristic and antifungal drug sensitivity of hepatic cirrhosis patients complicating spontaneous Aeromonas bacterial peritonitis

Abstract

Objective To study the clinical features and the sensitivity to antibacterials of hepatic cirrhosis patients complicating spontaneous bacterial peritonitis (SBP) caused by Aeromonas.Methods A retrospective,matched by age and sex case-control study (1:2 ratio) were carried out from 2001 to 2010.Case group included 31 hepatic cirrhosis patients complicating SBP caused by Aeromonas and control group included 62 hepatic cirrhosis patients complicating SBP caused by other organisms.Antimicrobial susceptibility test of Aeromonas isolated form case group was also conducted.Results In case group 29 patients (93.5 ％) infected Aeromonas hydrophila and 2 patients (6.5 ％) infected Aeromonas sorbia.There was no difference of baseline Child-Pugh class between case and control groups(x2 =1.452,P ＞ 0.05).Compared with control group,the infection rate during April-September period and the incidence rate of case group was significantly higher (x2 =22.024 and x2 =10.908,P all ＜ 0.01).The drag resistance rates of Aeromonas to imipenem and piporacillin/tazobactam were 54.8％ and 41.4％,respectively.The sensitive rotes of Aeromonas to amikacin,cefepime,ciprofloxacin,gentamicin and tobramycin were all over 90.0％.In case group septic shock was the independent risk predictor of in-hospital mortality (β =-4.768,RR =4.25,P ＜ 0.01).Conclusions Aeromonos species should be considered to be a causative organism of SBP in hepatic cirrhosis patients presenting with diarrheal episodes during the warm season,it is needed to pay particular attention to the prevention and treatment of septic shock.The antibacterial drugs,such as fourth-generation cephalosporins,aminoglycosides and fluoroquinolones are the first choice to remedy Aeromonas infections presently. Key words: Aeromonas ; Spontaneous bacterial peritonitis; Hepatic cirrhosis; Sensitivity; Risk factors