DPP-4 inhibitors and glucose homeostasis - From cell to bedside

Abstract

Type 2 Diabetes is the consequence of the disturbances of both α- and β-cell secretions.Glucagon-like peptide-1 ( GLP-1 ),which regulates the function of alpha and beta cells,has led to the emergence of a new class of oral anti-diabetic drugs.DPP-4 inhibitors,which increase the concentration of GLP-1 and consequently improve HbAlC,have become a choice for patients in different stages of diabetes. Key words: Diabetes mellitus,type 2 ; Glucagon-like peptide-1 ; DPP-4 inhibitor ;