DOXYCYCLINE INTAKE AND DISTRIBUTION IN THE BODY OF BROILER CHICKENS WITH ORNITHOBACTERIOSIS

Abstract

The clinical efficiency of the antibiotic is determined by its distribution in organs and tissues, the ability to penetrate the physiological and pathological barriers of the body. The article presents the results from a study of the intake, distribution, and excretion of doxycycline hyclate – the active substance of the antibiotic pollodoxin from the body of broiler chickens (the Cobb-500 cross) with ornithobacteriosis. It has been established that 24 hours after the pollodoxin solution application in broiler chickens with ornithobacteriosis, the highest content of its active substance (doxycycline hyclate) was found in the lungs, liver, slightly less – in the kidneys, and least – in the heart and pectoral muscles. After 48 and 72 hours, the content of doxycycline hyclate increases in the liver, kidneys, heart, and pectoral muscles compared to 24 hours, while in the lungs decreases slightly after 48 hours and does not differ from it after 72 hours. At 96 hours, the content of doxycycline hyclate in the kidneys, lungs, and pectoral muscles reaches maximum values; in the liver it is smaller than the previous one (72 hours), while in the heart it does not differ from it. Doxycycline hyclate does not show cumulative properties and “organ affiliation” during 96 hours of entry into the body of broiler chickens with ornithobacteriosis. After 24 hours of discontinuation of pollodoxin use (120 hours of the experiment), the content of doxycycline hyclate in all studied organs decreases but remains high enough, indicating a relatively long elimination half-life and antimicrobial action. Pharmacokinetic indicators will allow the doctor to determine an effective drug that will provide a therapeutic effect and will prevent the development of resistance of microorganisms. Keywords: pollodoxin, doxycycline hyclate, broiler chickens, ornithobacteriosis, Ornithobacterium rhinotracheale, pharmacokinetic parameters