Abstract
Objective: Periodontitis represents one of the main causes of teeth loss. In this preliminary study, we aimed to evaluate the efficacy of different modalities for treatment of chronic periodontitis. Method and Materials: 40 patients were divided into 4 groups: group I, received subantimicrobial dose doxycycline (SDD; 20mg) and standard scaling and root planning (SRP); group II, received Co enzyme Q10 (CoQ10; 30mg) and SRP; group III, received both drugs and SRP; group IV, received SRP only. Medications were administered twice/day for 3 months. Gingival, plaque and bleeding indices, probing pocket depth, clinical attachment level and Osteocalcin level in gingival crevicular fluid (GCF) were assessed. Results: A combination of SDD and CoQ10 showed the best therapeutic effect (P<0.05) compared to other modalities. Treatment with SDD or CoQ10 improved significantly (P<0.05) the clinical parameters when compared to SRP alone. No significant reduction or increase in GCF osteocalcin level was evident. Conclusion: Combination of SDD and CoQ10 drugs that were given twice per day for 3 months is of promising clinical outcomes. However, long-term studies on a larger number of patients are recommended to confirm or refute these findings and to explore the exact role of osteocalcin in periodontitis and its treatment modalities.
Highlights
Periodontal diseases are inflammatory disorders that affect 1015% of the population worldwide and represent one of the major causes of tooth loss
Combination of subantimicrobial dose doxycycline (SDD) and Co enzyme Q10 (CoQ10) drugs that were given twice per day for 3 months is of promising clinical outcomes
There were significant (P
Summary
Periodontal diseases are inflammatory disorders that affect 1015% of the population worldwide and represent one of the major causes of tooth loss. Such diseases result from complex interactions between periodontal pathogens and the host immune response [1]. Owing to the high prevalence, scientists have been attracted to research aimed to treat periodontal diseases; treatments are always challenging [2]. Host modulatory therapy (HMT) has been emerged as a treatment concept that aims to reduce tissue destruction and stabilize or even regenerate the periodontium by modifying or down regulating the host immune response [4]. HMT is systemically or locally delivered pharmaceuticals that are prescribed as a part of periodontal therapy and used as an adjunct to conventional periodontal treatment [5]
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