Abstract
See CORRECTIONSPECIFIC AIMSHuman diploid fibroblasts undergo multiple functional alterations during their senescence process. Most of all, senescent cells do not respond properly to external stimuli and do not uptake materials as efficiently as presenescent cells. To elucidate the reason for such attenuated response of senescent cells, we attempted to monitor the functional capacity and molecular mechanism for the clathrin-dependent, receptor-mediated endocytosis in the senescent cells, and tried to find principal molecules responsible for the decreased endocytotic activity in senescent cells that might be a target of intervention for the age-related dysfunctions.PRINCIPAL FINDINGS1. Clathrin-dependent receptor-mediated endocytosis is blocked in senescent human diploid fibroblastsTo investigate the functional changes in the receptor-mediated endocytosis during cellular senescence, we treated the early and late-passaged fibroblasts with tetramethylrhodamine-conjugated transferrin. Presenescent fibroblasts ...
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