Abstract
Various sub-fractions of vertebrate nuclear DNA were isolated and examined for sequence-dependent characteristics by nearest neighbour base-sequence (doublet) analysis. These include density, renaturation rate, satellite, chromatin and ribosomal cistron DNA fractions. The results of the analyses were compared together with sequence properties of 5S RNA and transfer RNA, in order to establish degrees of relationship. It was found that all sub-fractions showed very similar patterns of deviation from random expectation (general designs) except those fractions which on theoretical grounds are expected not to be directly involved in coding for polypeptides (satellite DNAs, ribosomal cistron DNA, DNA coding for 5 S RNA and tRNA). These findings are considered in relation to the still limited information available for mammalian messenger RNA sequences and to the doublet frequency properties of the DNAs of small genome viruses of mammals. It is concluded that the highly characteristic general design of bulk nDNA † , and of the majority of individual sub-fractions of nDNA, is shared by those fractions of nDNA that code for proteins which in turn implies that they have all evolved in response to the same major selection pressures.
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