Abstract
AbstractAn effective and novel heterogeneous beta zeolite supported CuO (Cuβ) catalyzed double hydroamination of alkynes for the synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones has been achieved in a solvent‐free condition. Cuβ zeolite was synthesized by impregnation method. The synthesized Cuβ was characterized by X‐ray diffraction, Fourier transformation infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, and X‐ray photoelectron spectroscopy. Pure Hβ (18 % yield) or Nano CuO (44 % yield) displayed poor catalytic activity, whereas 1 % Cuβ (96 % yield) showed higher catalytic activity for double hydroamination of alkynes due to the synergistic effect of CuO and Hβ zeolite in the reaction. The new protocol offers an appealing approach to a number of di‐substituted quinazolinones with decent to excellent yields. The catalyst has been successfully recycled for up to 5 consecutive cycles.
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