Abstract
In this work, a double crosslinking strategy comprising chemical crosslinking and physical crosslinking was applied to fabricate novel polyvinyl alcohol/gelatin/silver sulfadiazine (PGA) sponges. The morphology and chemical composition were characterized via Environmental Scanning Electron Microscopy and Fourier-transform infrared spectroscopy. The antibacterial activity of PGA sponges towards Escherichia coli, Candida albicans, and Staphylococcus aureus was evaluated via several methods: inhibition zone determination, plate counting, fluorescence staining of dead/live bacteria, bacterial morphology observation, and protein leakage determination. The PGA sponges exhibited excellent antibacterial performance owing to the silver sulfadiazine release from the sponges. Moreover, the sponges exhibited sustained sulfadiazine release, and the release profiles reasonably fitted the Higuchi model, indicating that the release was diffusion controlled. The improved mechanical properties and excellent antibacterial effect of the prepared PGA sponges demonstrate their potential as outstanding antibacterial materials.
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