Dosimetric Impact of Patient Rotational Setup Errors with Frameless Single-Isocenter, Multi-Target Volumetric Modulated Arc Radiosurgery for Multiple Brain Metastases

Abstract

Conclusions: Significant image contrast was observed for concentrations 4 mg/ml and higher. Previous pre-clinical work has shown that average concentrations of 7 mg/ml may be delivered in vivo. Based on the results of this study, it may be possible to use gold nanoparticles as a contrast agent for image-guided therapy targeting or for image-based kinetic studies of tumor uptake. Future work will include in vivo targeting studies with gold nanoparticles in tumor-bearing mice. Author Disclosure: H. Korideck: None. W. Ngwa: None. M. Makrigiorgos: None. R.I. Barbeco: None.