Abstract
Literature on the relationship between lead-in-blood levels (PbB) and various biochemical and hematological responses are reviewed. The percentage of subjects with a specified intensity of a specified response in groups of subjects was calculated in relation to PbB. This Dose-Response (D-R) relationship showed an increase of biological effects with increasing internal dose, qualitatively and quantitatively, and can be used to evaluate the significance of Pb exposure in occupational and public health. D-R curves were calculated for delta-aminolevulinic acid dehydratase activity in erythrocytes, delta-aminolevulinic acid excretion in urine, protoporphyrin in erythrocytes, sodium ion, potassium ion, and ATPase activity in erythrocytes, and reduced glutathion content of erythrocytes. Other biochemical and hematological responses are discussed with regard to their relationship with PbB.
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