Abstract
Patients with duodenal ulcer were given intravenous injections of 0.1, 0.2, and 0.4 U per kg of insulin on different days. In each of 8 patients the peak acid output was higher after 0.2 U per kg than after 0.1 U per kg and the difference was significant. In 19 patients the peak acid output after 0.2 U per kg was significantly higher than after 0.4 U per kg. The mean lowest blood glucose concentration was significantly lower after the larger dose of insulin. These results support the concept that insulin-stimulated acid secretion is not an all or none phenomenon but is dose-related and also hypoglycemia-related. An optimum dose of insulin is proposed for gastric function tests and defined as That dose which in most subjects lowers the blood glucose concentration sufficiently to allow near-maximum vagal stimulation to occur without producing so low a blood glucose concentration that acid secretion is depressed. The desirable range of blood glucose concentration is probably about 15 to 25 mg per 100 ml.
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