Abstract
Eight studies of gastric acid secretion in a basal hour and after a single intravenous injection of soluble insulin (0.003–0.4 units/kg) were performed in a healthy man. The peak acid output after insulin was significantly correlated with the lowest concentrations of blood glucose and the maximum fall in blood glucose. Peak acid output increased linearly with log dose of insulin up to a dose of 0.05 units/kg, and higher doses evoked a smaller response. Insulin-stimulated acid secretion is dose-dependent, although the dose of insulin which produces the greatest acid output varies between individuals. Insulin hypoglycaemia produces a quantitative vagal acid response, a blood glucose of about 25 mg/100 ml is associated with the greatest acid stimulation, and blood glucose concentration below 15 mg/100 ml is associated with inhibition of acid secretion.
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