Abstract
The kinetics of some drugs may reflect first pass nonlinearity and therefore the usual assumption of zero intercept may be invalid. Current statistical methods used to evaluate dose linearity with respect to kinetic variables do not seem to be appropriate in this context. In this paper we fit a stepwise polynomial regression to the data obtained from a within-subject design assuming multivariate normality with a special structure on the dispersion matrix. The proposed method is illustrated with a numerical example.
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